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Hesitant: Dr. Byram Bridle, Viral Immunologist
University of Guelph, Ontario, Canada

Why Parents, Teens, and Children Should Question the COVID-19 Vaccine


A short, well-cited memo published by Dr. Bridle highlighting how much is unknown about the potential, lasting presence of the mRna vaccine in the body. Cites several peer-reviewed studies that conclude that the mRna vaccine itself and the spike proteins it produces are shown to circulate throughout the body and potentially cluster in certain organs, most notably the ovaries. See note at bottom of p.2 about how the toxicity tests on spike proteins conducted by Pfizer may not give sufficient information to confidently say that spike proteins are not toxic. 


Referenced by Dr. Bridle: Japanese Pfizer study where mRna vaccine was administered to rats and indicates that vaccine lipid nanoparticles did gather in various organs, especially the ovaries, post-vaccination:


This study has caused Dr. Bridle to ask these questions: Can elements of the vaccines linger in the body? If so, could this cause harm? Vaccines should not be mandated, and they should be potentially pulled off the market until there is more clarity regarding these questions. 


Rebuttals to Dr. Bridle:


Debunking Concerns About Spike Proteins


Well-sourced, easy to understand article thoroughly addressing concerns about the spread of vaccine spike proteins throughout the body and the safety of the spike proteins themselves. Directly responds to vaccine concerns raised by Dr. Bridle (link) and Dr. Malone (link).


Main points from article: 


The Japanese biodistribution study that is cited as evidence that the spike proteins and nanoparticles from the vaccine itself are spreading and clustering in unwanted areas of the body has been misinterpreted. Also, the amount of the vaccine used in this study (which was conducted on rats) is much higher than the dosage used on humans. Likewise, there is no evidence that the tiny amounts of vaccine that may end up in the ovaries will actually produce spike proteins in the ovarian cells and even if they did it is unlikely that they would be harmful. 


Spike proteins engineered for the vaccine are DIFFERENT from the one’s produced directly by Covid-19 itself. Many studies cited by vaccine-hesitant doctors are studies done on spike proteins produced by Covid-19 itself, not the mRna vaccines. Hence, the data from these studies that point to spike proteins spreading and being toxic may not be relevant. 


From conclusion: 

“In brief, while it’s true that the mRNA vaccine has a broad biodistribution in our body and that the spike proteins of SARS-CoV-2 are dangerous, the narrative doesn't end there. Minuscule amounts of mRNA vaccine entering other tissues or organs are only of minuscule significance, and membrane-anchored spike proteins from the vaccines are not dangerous. Although there will always be people and even experts who insist otherwise, let’s stay informed to differentiate between a good and bad scientific argument.”


Direct Response to Dr. Bridle’s Concerns:

COVID-19 Vaccine-Generated Spike Protein is Safe, Contrary to Viral Claims

Well-sourced article that responds to Dr. Bridle’s specific concerns about spike protein toxicity and the potential for spike proteins to spread to unwanted areas of the body through the bloodstream. Citing various doctors and medical professionals, this article points out that the spike protein generated by the mRna vaccines is engineered to be slightly different from the spike protein produced by Covid-19 itself, thus rendering it safe. Article also points out that Dr. Bridle’s interpretation of studies on spike proteins circulating throughout the body may be a misinterpretation of the studies done on this topic.



Direct Study Describing How the Vaccine Spike Proteins are Modified to be “Safer.”


December 2020 Peer-Reviewed Study on Potential Long-Term Toxicity of the Spike Proteins Produced by the Covid-19 mRna Vaccines



This analysis suggests that the SARS-CoV-2 spike protein. . . have the capacity to trigger cell biological events that may lead to the development of pulmonary vascular remodeling and, perhaps, clinically significant PAH, a fatal condition. Given the observations that cells sensitively respond to the spike protein at pM concentrations in cultured cells [10], it is likely that the SARS-CoV-2 spike protein not only facilitates the viral entry and serves to acquire immunity as an antigen for vaccines but, also, targets host cells and may exert adverse effects (Figure 4). Further experiments should be performed to address the possible effects of the SARS-CoV-2 spike protein on developing PAH. The effects of the SARS-CoV-2 spike protein on the cells of other tissues/organs, such as those of the systemic vasculature, heart, and brain, should also be investigated. Given that this protein will be administered as vaccines to millions and possibly billions of people, it is critical to understand the extracellular and intracellular effects of the SARS-CoV-2 spike protein on human cells that may promote long-term adverse health consequences.


January 2021 Peer-Reviewed Study Citing Evidence That the Spike Protein Produced by the Covid-19 mRna Vaccine May Have the Potential to Change Human Host Cells (which may or may not be harmful).


Excerpt from Study Conclusion: 


“. . . we need to consider. . . the. . . long-term consequences [of the vaccine] carefully, especially when they are administered to otherwise healthy individuals as well as young adults and children. . . further investigations of the effects of the SARS-CoV-2 spike protein in human cells and appropriate animal models are warranted.


September 2020 Study on the Potential For Covid-19 Spike Proteins to Contribute to Enhanced Blood Clotting

Study Conclusion: 

“Our findings uncovered a novel function of SARS-CoV-2 on platelet activation via binding of Spike to ACE2. SARS-CoV-2-induced platelet activation may participate in thrombus (blood clot) formation and inflammatory responses in COVID-19 patients.”

Fact-Check Article That Allegedly Debunks Claims That the Spike Proteins Could be Toxic and that the Covid-19 Vaccine Freely Circulates Throughout the Body


Note: This article cites Dr. Drew Weissman and Dr. Katalin Kariko, who both work for BioNTech, the pharmaceutical company that produces the Pfizer vaccine. Could be a conflict of interest? It does point out some potential holes in Dr. Bridle’s reasons for concern about the mRna vaccines. However, this article does not directly engage with most of the sources that Dr. Bridle cites for his concerns, so it ultimately felt like a weak “fact-check” to me. 

How the Spike Protein in the mRna Vaccines Behaves:

Derek Lowe, Ph.D in Organic Chemistry

Explains why the spike proteins are not circulating throughout your body post-vaccine and therefore cannot be clustering in your organs, causing damage. 


The spike proteins from the vaccine are largely not in the bloodstream, and when they are in the bloodstream, it is safe, due to the fact that the spike proteins are “free agents” in the bloodstream, but rather tightly bound to the cell that they affect. Notes that Pfizer BioNTech did a biodistribution study on the mRna vaccine spreads throughout the body using radioactive tags on the vaccines and notes that almost all the radioactivity stayed near the injection site, quickly dissolved and that the rest went to the liver, with only 1% going to other organs. 

Fact Check: COVID-19 vaccines are not ‘cytotoxic’

A brief article directly citing several physicians who claim to debunk the myth of spike protein toxicity. This article is directly responding to claims made by Dr. Robert Malone and Dr. Bret Weinstein about spike protein toxicity. However, this article does not directly engage with the specifics of Malone and Weinstein’s claims but simply indicates that what they are saying is false. 


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